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Document type:
journal article 
Author(s):
Zhou, Cheng; Moustafa, Mahmoud R; Cao, Liji; Kriegsmann, Mark; Winter, Martin; Schwager, Christian; Jones, Bleddyn; Wang, Shijun; Bäuerle, Tobias; Zhou, Ping-Kun; Schnölzer, Martina; Weichert, Wilko; Debus, Juergen; Abdollahi, Amir 
Title:
Modeling and multiscale characterization of the quantitative imaging based fibrosis index reveals pathophysiological, transcriptome and proteomic correlates of lung fibrosis induced by fractionated irradiation. 
Abstract:
Pulmonary fibrosis represents a leading cause of morbidity and mortality worldwide. Therapy induced lung fibrosis constitutes a pivotal dose-limiting side effect of radiotherapy and other anticancer agents. We aimed to develop objective criteria for assessment of fibrosis and discover pathophysiological and molecular correlates of lung fibrosis as a function of fractionated whole thoracic irradiation. Dose-response series of fractionated irradiation was utilized to develop a non-invasive and qua...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2019 
Journal volume:
144 
Journal issue:
12 
Pages contribution:
3160-3173 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0020-7136 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie