User: Guest  Login
Document type:
journal article 
Author(s):
Schneeweis, Christian; Wirth, Matthias; Saur, Dieter; Reichert, Maximilian; Schneider, Günter 
Title:
Oncogenic KRAS and the EGFR loop in pancreatic carcinogenesis-A connection to licensing nodes. 
Abstract:
EGFR signaling has a critical role in oncogenic KRAS-driven tumorigenesis of the pancreas, whereas it is dispensable in other organs. The complex signaling network engaged by oncogenic KRAS and its modulation by EGFR signaling, remains incompletely understood. In order to study early signaling events activated by oncogenic KRAS in the pancreas, we recently developed a novel model system based on murine primary pancreatic epithelial cells enabling the time-specific expression of mutant Kras from...    »
 
Journal title abbreviation:
Small GTPases 
Year:
2018 
Journal volume:
Journal issue:
Pages contribution:
457-464 
Language:
eng 
Print-ISSN:
2154-1248 
TUM Institution:
Klinik und Poliklinik für Innere Medizin II