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Document type:
Zeitschriftenaufsatz 
Author(s):
Aschenbrenner, M.; Kulozik, U.; Foerst, P. 
Title:
In situ determination of the physical state of biological samples during freeze drying 
Abstract:
The proceeding change of water content in a freeze-drying process, as well as the physical state of cell--sugar suspensions with Lactobacillus paracasei ssp. paracasei, was monitored by means of an in situ weighing system. Due to the pressure and temperature variations in the drying chamber, the weighing system was found to be influenced. This deviation of the weighing system was quantified by means of drying simulations with drying-inert Teflon dummies. This quantified deviation could be used f...    »
 
Keywords:
Freeze-drying; Glassy state; In situ measurement; Physical state; residual water content 
Journal title:
Drying Technology 
Year:
2011 
Journal volume:
29 
Pages contribution:
461--471