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Document type:
journal article 
Author(s):
Xia, Yuchen; Cheng, Xiaoming; Blossey, Christoph K; Wisskirchen, Karin; Esser, Knud; Protzer, Ulrike 
Title:
Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro. 
Abstract:
Interferon- (IFN-) has been used for more than 20 years as the first-line therapy for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, because it has a number of antiviral effects. In this study, we describe a novel mode of its antiviral action. We demonstrate that the supernatant from IFN--treated cultured cells restricted HBV and HCV infection by inhibiting viral entry into hepatoma cells. The factors contained in the supernatant competed with the virus for binding to heparan gly...    »
 
Journal title abbreviation:
J Immunol Res 
Year:
2017 
Journal volume:
2017 
Pages contribution:
4828936 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
2314-7156 
TUM Institution:
Institut für Virologie