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Document type:
journal article 
Author(s):
Nystoriak, Matthew A; Nieves-Cintrón, Madeline; Patriarchi, Tommaso; Buonarati, Olivia R; Prada, Maria Paz; Morotti, Stefano; Grandi, Eleonora; Fernandes, Julia Dos Santos; Forbush, Katherine; Hofmann, Franz; Sasse, Kent C; Scott, John D; Ward, Sean M; Hell, Johannes W; Navedo, Manuel F 
Title:
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. 
Abstract:
Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in part, attributed to the effects of increased glucose (hyperglycemia) on L-type Ca1.2 channels. In murine arterial myocytes, kinase-dependent mechanisms mediate the increase in Ca1.2 activity in response to increased extracellular glucose. We identified a subpopulation of the Ca1.2 channel pore-forming subunit (?1) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human ar...    »
 
Journal title abbreviation:
Sci Signal 
Year:
2017 
Journal volume:
10 
Journal issue:
463 
Language:
eng 
TUM Institution:
Institut für Pharmakologie und Toxikologie