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Document type:
journal article 
Author(s):
Wang, Rui; Islam, Bianca N; Bridges, Allison; Sharman, Sarah K; Hu, Muhan; Hou, Yali; Somanath, Payaningal R; Venable, Laine; Singh, Nagendra; Kim, Sangmi; Sridhar, Subbaramiah; Hofmann, Franz; Browning, Darren D 
Title:
cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium. 
Abstract:
Signaling through cGMP has therapeutic potential in the colon, where it has been implicated in the suppression of colitis and colon cancer. In this study, we tested the ability of cGMP and type 2 cGMP-dependent protein kinase (PKG2) to activate forkhead box O (FoxO) in colon cancer cells and in the colon epithelium of mice. We show that activation of PKG2 in colon cancer cells inhibited cell proliferation, inhibited AKT, and activated FoxO. Treatment of colon explants with 8Br-cGMP also activate...    »
 
Journal title abbreviation:
Am J Pathol 
Year:
2017 
Journal volume:
187 
Journal issue:
Pages contribution:
377-389 
Language:
eng 
Print-ISSN:
0002-9440 
TUM Institution:
Institut für Pharmakologie und Toxikologie