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Document type:
journal article 
Author(s):
Hinz, Laura; Ahles, Andrea; Ruprecht, Benjamin; Küster, Bernhard; Engelhardt, Stefan 
Title:
Two serines in the distal C-terminus of the human ß1-adrenoceptor determine ß-arrestin2 recruitment. 
Abstract:
G protein-coupled receptors (GPCRs) undergo phosphorylation at several intracellular residues by G protein-coupled receptor kinases. The resulting phosphorylation pattern triggers arrestin recruitment and receptor desensitization. The exact sites of phosphorylation and their function remained largely unknown for the human ?1-adrenoceptor (ADRB1), a key GPCR in adrenergic signal transduction and the target of widely used drugs such as ?-blockers. The present study aimed to identify the intracellu...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2017 
Journal volume:
12 
Journal issue:
Pages contribution:
e0176450 
Language:
eng 
TUM Institution:
Institut für Pharmakologie und Toxikologie