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Document type:
journal article 
Author(s):
Werfel, Stanislas; Leierseder, Simon; Ruprecht, Benjamin; Kuster, Bernhard; Engelhardt, Stefan 
Title:
Preferential microRNA targeting revealed by in vivo competitive binding and differential Argonaute immunoprecipitation. 
Abstract:
MicroRNAs (miRNAs) have been described to simultaneously inhibit hundreds of targets, albeit to a modest extent. It was recently proposed that there could exist more specific, exceptionally strong binding to a subgroup of targets. However, it is unknown, whether this is the case and how such targets can be identified. Using Argonaute2-ribonucleoprotein immunoprecipitation and in vivo competitive binding assays, we demonstrate for miRNAs-21, -199-3p and let-7 exceptional regulation of a subset of...    »
 
Journal title abbreviation:
Nucleic Acids Res 
Year:
2017 
Journal volume:
45 
Journal issue:
17 
Pages contribution:
10218-10228 
Language:
eng 
Print-ISSN:
0305-1048 
TUM Institution:
Institut für Pharmakologie und Toxikologie