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Document type:
journal article 
Author(s):
Wang, Jialu; Hanada, Kenji; Staus, Dean P; Makara, Michael A; Dahal, Giri Raj; Chen, Qiang; Ahles, Andrea; Engelhardt, Stefan; Rockman, Howard A 
Title:
G? is required for carvedilol-induced ? adrenergic receptor ?-arrestin biased signaling. 
Abstract:
The ? adrenergic receptor (?AR) is recognized as a classical G?-coupled receptor. Agonist binding not only initiates G protein-mediated signaling but also signaling through the multifunctional adapter protein ?-arrestin. Some ?AR ligands, such as carvedilol, stimulate ?AR signaling preferentially through ?-arrestin, a concept known as ?-arrestin-biased agonism. Here, we identify a signaling mechanism, unlike that previously known for any G?-coupled receptor, whereby carvedilol induces the transi...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
1706 
Language:
eng 
TUM Institution:
Institut für Pharmakologie und Toxikologie