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Document type:
journal article 
Author(s):
Sassi, Yassine; Avramopoulos, Petros; Ramanujam, Deepak; Grüter, Laurenz; Werfel, Stanislas; Giosele, Simon; Brunner, Andreas-David; Esfandyari, Dena; Papadopoulou, Aikaterini S; De Strooper, Bart; Hübner, Norbert; Kumarswamy, Regalla; Thum, Thomas; Yin, Xiaoke; Mayr, Manuel; Laggerbauer, Bernhard; Engelhardt, Stefan 
Title:
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. 
Abstract:
Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium. The microRNA-29 (miR-29) family has been found to prevent excess collagen expression in various organs, particularly through its function in fibroblasts. Here, we show that miR-29 promotes pathologic hypertrophy of cardiac myocytes and overall cardiac dysfunction. In a mouse model of cardiac pressure overload, global genetic deletion of miR-29 or antimiR-29 infusion prevents cardiac hypertrophy and fibrosis and...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
1614 
Language:
eng 
TUM Institution:
Institut für Pharmakologie und Toxikologie