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Document type:
journal article 
Author(s):
Toischer, Karl; Zhu, Wuqiang; Hünlich, Mark; Mohamed, Belal A; Khadjeh, Sara; Reuter, Sean P; Schäfer, Katrin; Ramanujam, Deepak; Engelhardt, Stefan; Field, Loren J; Hasenfuss, Gerd 
Title:
Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload. 
Abstract:
Induction of the cell cycle is emerging as an intervention to treat heart failure. Here, we tested the hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be beneficial during hemodynamic overload. We induced pressure overload by transthoracic aortic constriction (TAC) or volume overload by aortocaval shunt in cyclin D2-expressing and WT mice. Although cyclin D2 expression dramatically improved survival following TAC, it did not confer a survival advantag...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2017 
Journal volume:
127 
Journal issue:
12 
Pages contribution:
4285-4296 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
Institut für Pharmakologie und Toxikologie