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Document type:
journal article 
Author(s):
Poomvanicha, Montatip; Matthes, Jan; Domes, Katrin; Patrucco, Enrico; Angermeier, Elisabeth; Laugwitz, Karl-Ludwig; Schneider, Toni; Hofmann, Franz 
Title:
Beta-adrenergic regulation of the heart expressing the Ser1700A/Thr1704A mutated Cav1.2 channel. 
Abstract:
Beta-adrenergic stimulation of the heart increases I. PKA dependent phosphorylation of several amino acids (among them Ser 1700 and Thr 1704 in the carboxy-terminus of the Cav1.2 ?c subunit) has been implicated as decisive for the ?-adrenergic up-regulation of cardiac I. Mutation of Ser 1700 and Thr 1704 to alanine results in the Cav1.2PKA_P2 mice. Cav1.2PKA_P2 mice display reduced cardiac L-type current. Fractional shortening and ejection fraction in the intact animal and I in isolated cardiomy...    »
 
Journal title abbreviation:
J Mol Cell Cardiol 
Year:
2017 
Journal volume:
111 
Pages contribution:
10-16 
Language:
eng 
Print-ISSN:
0022-2828 
TUM Institution:
Klinik und Poliklinik für Innere Medizin I; Institut für Pharmakologie und Toxikologie