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Document type:
journal article 
Author(s):
Strangfeld, A; Richter, A; Siegmund, B; Herzer, P; Rockwitz, K; Demary, W; Aringer, M; Meißner, Y; Zink, A; Listing, J 
Title:
Risk for lower intestinal perforations in patients with rheumatoid arthritis treated with tocilizumab in comparison to treatment with other biologic or conventional synthetic DMARDs. 
Abstract:
To investigate the risk of developing lower intestinal perforations (LIPs) in patients with rheumatoid arthritis (RA) treated with tocilizumab (TCZ).In 13 310 patients with RA observed in the German biologics register heumatoid rthritis: Oservation of ologic herapy, 141 serious gastrointestinal events possibly associated with perforations were reported until 31 October 2015. All events were validated independently by two physicians, blinded for treatment exposure.37 LIPs (32 in the colon/sigma)...    »
 
Journal title abbreviation:
Ann Rheum Dis 
Year:
2017 
Journal volume:
76 
Journal issue:
Pages contribution:
504-510 
Language:
eng 
Print-ISSN:
0003-4967 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie