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Document type:
journal article 
Author(s):
Malysz, John; Gibbons, Simon J; Saravanaperumal, Siva A; Du, Peng; Eisenman, Seth T; Cao, Chike; Oh, Uhtaek; Saur, Dieter; Klein, Sabine; Ordog, Tamas; Farrugia, Gianrico 
Title:
Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca transients and slow waves in adult mouse small intestine. 
Abstract:
Myenteric plexus interstitial cells of Cajal (ICC-MY) in the small intestine are Kit electrical pacemakers that express the Ano1/TMEM16A Ca-activated Cl channel, whose functions in the gastrointestinal tract remain incompletely understood. In this study, an inducible Cre-LoxP-based approach was used to advance the understanding of Ano1 in ICC-MY of adult mouse small intestine. mice were treated with tamoxifen or vehicle, and small intestines (mucosa free) were examined. Quantitative RT-PCR demo...    »
 
Journal title abbreviation:
Am J Physiol Gastrointest Liver Physiol 
Year:
2017 
Journal volume:
312 
Journal issue:
Pages contribution:
G228-G245 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0193-1857 
TUM Institution:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur); Klinik und Poliklinik für Innere Medizin II