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Document type:
journal article 
Author(s):
Ziegler, Tilman; Kraus, Markus; Husada, Wira; Gesenhues, Florian; Jiang, Qui; Pinkenburg, Olaf; Trenkwalder, Teresa; Laugwitz, Karl-Ludwig; le Noble, Ferdinand; Weber, Christian; Kupatt, Christian; Hinkel, Rabea 
Title:
Steerable Induction of the Thymosin ?4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization. 
Abstract:
Viral vectors have been frequently used in a variety of preclinical animal models to deliver genetic constructs into tissues. Among the vectors used, adeno-associated viral vectors (AAVs) may be targeted to specific tissues, depending on the serotype used. Moreover, they show robust expression for prolonged periods of time and have a low immunogenic potential. Furthermore, AAVs, unlike other vector systems, only display a low rate of genomic integration. However, to ensure efficient transgene pr...    »
 
Journal title abbreviation:
Hum Gene Ther 
Year:
2017 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1043-0342 
TUM Institution:
Klinik und Poliklinik für Innere Medizin I