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Dokumenttyp:
journal article 
Autor(en):
Stojanovic, N; Hassan, Z; Wirth, M; Wenzel, P; Beyer, M; Schäfer, C; Brand, P; Kroemer, A; Stauber, R H; Schmid, R M; Arlt, A; Sellmer, A; Mahboobi, S; Rad, R; Reichert, M; Saur, D; Krämer, O H; Schneider, G 
Titel:
HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer. 
Abstract:
Mutation of p53 is a frequent genetic lesion in pancreatic cancer being an unmet clinical challenge. Mutants of p53 have lost the tumour-suppressive functions of wild type p53. In addition, p53 mutants exert tumour-promoting functions, qualifying them as important therapeutic targets. Here, we show that the class I histone deacetylases HDAC1 and HDAC2 contribute to maintain the expression of p53 mutants in human and genetically defined murine pancreatic cancer cells. Our data reveal that the inh...    »
 
Zeitschriftentitel:
Oncogene 
Jahr:
2017 
Band / Volume:
36 
Heft / Issue:
13 
Seitenangaben Beitrag:
1804-1815 
Sprache:
eng 
Print-ISSN:
0950-9232 
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin II; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)