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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Kramer, Sigrid; Sellge, Gernot; Lorentz, Axel; Krueger, Dagmar; Schemann, Michael; Feilhauer, Katharina; Gunzer, Florian; Bischoff, Stephan C. 
Titel:
Selective activation of human intestinal mast cells by {Escherichia} coli hemolysin. 
Abstract:
Mast cells (MCs) are recognized to play an important role in bacterial host defense in the murine system. In this study, we studied the interaction of human MCs, isolated from the intestine and purified to homogeneity, with different Escherichia coli and Shigella flexneri strains. We show that alpha-hemolysin (Hly)-producing E. coli strains induce the release of histamine, leukotrienes, and proinflammatory cytokines in intestinal MCs. In contrast, MCs were virtually unresponsive to S. flexneri...    »
 
Stichworte:
Cells, Cultured, Calcium/metabolism, Humans, *Histamine Release, Cytokines/immunology/metabolism, Escherichia coli Proteins/immunology/metabolism, Escherichia coli/*immunology, Hemolysin Proteins/*immunology/metabolism, Inflammation Mediators/immunology/*metabolism, Intestinal Mucosa/cytology/*immunology/microbiology, Leukotrienes/immunology/metabolism, Lymphocyte Activation, Mast Cells/*immunology/metabolism/microbiology, Mitogen-Activated Protein Kinase Kinases/*metabolism 
Zeitschriftentitel:
Journal of immunology (Baltimore, Md. : 1950) 
Jahr:
2008 
Band / Volume:
181 
Monat:
jul 
Heft / Issue:
Seitenangaben Beitrag:
1438--1445 
Sprache:
eng 
Print-ISSN:
1550-6606 0022-1767