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Dokumenttyp:
journal article 
Autor(en):
Liu, Yang; Sethi, Nilay S; Hinoue, Toshinori; Schneider, Barbara G; Cherniack, Andrew D; Sanchez-Vega, Francisco; Seoane, Jose A; Farshidfar, Farshad; Bowlby, Reanne; Islam, Mirazul; Kim, Jaegil; Chatila, Walid; Akbani, Rehan; Kanchi, Rupa S; Rabkin, Charles S; Willis, Joseph E; Wang, Kenneth K; McCall, Shannon J; Mishra, Lopa; Ojesina, Akinyemi I; Bullman, Susan; Pedamallu, Chandra Sekhar; Lazar, Alexander J; Sakai, Ryo; Cancer Genome Atlas Research Network; Thorsson, Vésteinn; Bass, Adam J; La...    »
 
Titel:
Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. 
Abstract:
We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island methylator phenotype, plus tumors with elevated single-nucleotide variants associated...    »
 
Zeitschriftentitel:
Cancer Cell 
Jahr:
2018 
Band / Volume:
33 
Heft / Issue:
Seitenangaben Beitrag:
721-735.e8 
Sprache:
eng 
Print-ISSN:
1535-6108 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie