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Dokumenttyp:
journal article 
Autor(en):
Wisskirchen, Karin; Metzger, Kai; Schreiber, Sophia; Asen, Theresa; Weigand, Luise; Dargel, Christina; Witter, Klaus; Kieback, Elisa; Sprinzl, Martin F; Uckert, Wolfgang; Schiemann, Matthias; Busch, Dirk H; Krackhardt, Angela M; Protzer, Ulrike 
Titel:
Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use. 
Abstract:
T-cell therapy of chronic hepatitis B is a novel approach to restore antiviral T-cell immunity and cure the infection. We aimed at identifying T-cell receptors (TCR) with high functional avidity that have the potential to be used for adoptive T-cell therapy. To this end, we cloned HLA-A*02-restricted, hepatitis B virus (HBV)-specific T cells from patients with acute or resolved HBV infection. We isolated 11 envelope- or core-specific TCRs and evaluated them in comprehensive functional analyses....    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2017 
Band / Volume:
12 
Heft / Issue:
Seitenangaben Beitrag:
e0182936 
Sprache:
eng 
TUM Einrichtung:
Institut für Virologie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Innere Medizin III