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Document type:
journal article 
Author(s):
Ronchi, Cristina L; Peverelli, Erika; Herterich, Sabine; Weigand, Isabel; Mantovani, Giovanna; Schwarzmayr, Thomas; Sbiera, Silviu; Allolio, Bruno; Honegger, Jürgen; Appenzeller, Silke; Lania, Andrea G; Reincke, Martin; Calebiro, Davide; Spada, Anna; Buchfelder, Michael; Flitsch, Joerg; Strom, Tim M; Fassnacht, Martin 
Title:
Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas. 
Abstract:
Alterations in the cAMP signaling pathway are common in hormonally active endocrine tumors. Somatic mutations at GNAS are causative in 30-40% of GH-secreting adenomas. Recently, mutations affecting the USP8 and PRKACA gene have been reported in ACTH-secreting pituitary adenomas and cortisol-secreting adrenocortical adenomas respectively. However, the pathogenesis of many GH-secreting adenomas remains unclear.Comprehensive genetic characterization of sporadic GH-secreting adenomas and identificat...    »
 
Journal title abbreviation:
Eur J Endocrinol 
Year:
2016 
Journal volume:
174 
Journal issue:
Pages contribution:
363-72 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0804-4643 
TUM Institution:
Institut für Humangenetik