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Document type:
journal article 
Author(s):
Rhayem, Yara; Perez-Rivas, Luis G; Dietz, Anna; Bathon, Kerstin; Gebhard, Christian; Riester, Anna; Mauracher, Brigitte; Gomez-Sanchez, Celso; Eisenhofer, Graeme; Schwarzmayr, Thomas; Calebiro, Davide; Strom, Tim M; Reincke, Martin; Beuschlein, Felix 
Title:
PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas. 
Abstract:
Somatic mutations have been found causative for endocrine autonomy in aldosterone-producing adenomas (APAs). Whereas mutations of PRKACA (catalytic subunit of protein kinase A) have been identified in cortisol-producing adenomas, the presence of PRKACA variants in APAs is unknown, especially in those that display cosecretion of cortisol.The objective of the study was to investigate PRKACA somatic variants identified in APA cases.Identification of PRKACA somatic variants in APAs by whole-exome se...    »
 
Journal title abbreviation:
J Clin Endocrinol Metab 
Year:
2016 
Journal volume:
101 
Journal issue:
Pages contribution:
3010-7 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0021-972X 
TUM Institution:
Institut für Humangenetik