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Dokumenttyp:
journal article 
Autor(en):
Rhayem, Yara; Perez-Rivas, Luis G; Dietz, Anna; Bathon, Kerstin; Gebhard, Christian; Riester, Anna; Mauracher, Brigitte; Gomez-Sanchez, Celso; Eisenhofer, Graeme; Schwarzmayr, Thomas; Calebiro, Davide; Strom, Tim M; Reincke, Martin; Beuschlein, Felix 
Titel:
PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas. 
Abstract:
Somatic mutations have been found causative for endocrine autonomy in aldosterone-producing adenomas (APAs). Whereas mutations of PRKACA (catalytic subunit of protein kinase A) have been identified in cortisol-producing adenomas, the presence of PRKACA variants in APAs is unknown, especially in those that display cosecretion of cortisol.The objective of the study was to investigate PRKACA somatic variants identified in APA cases.Identification of PRKACA somatic variants in APAs by whole-exome se...    »
 
Zeitschriftentitel:
J Clin Endocrinol Metab 
Jahr:
2016 
Band / Volume:
101 
Heft / Issue:
Seitenangaben Beitrag:
3010-7 
Sprache:
eng 
Print-ISSN:
0021-972X 
TUM Einrichtung:
Institut für Humangenetik