Stent malapposition and the risk of stent thrombosis: mechanistic insights from an in vitro model.

Document type:: Journal Article
Author(s):: Foin, Nicolas; Lu, Shengjie; Ng, Jaryl; Bulluck, Heerajnarain; Hausenloy, Derek J; Wong, Philip E; Virmani, Renu; Joner, Michael
Title:: Stent malapposition and the risk of stent thrombosis: mechanistic insights from an in vitro model.
Abstract:: The aim of this report was to examine the effect of underexpansion on stent thrombogenicity with an in vitro perfusion model.Drug-eluting stent (DES) samples were partially underdeployed in silicone tubes and perfused with porcine blood containing 10% anticoagulant citrate dextrose solution for four minutes at a flow rate of 200 ml/min. Thrombus formation was evaluated and compared between the well-apposed and malapposed sections. The malapposed sections showed significantly more thrombus formation compared to the well-apposed sections (13.9 vs. 0.41 mm2, p<0.001).Stent malapposition has a very direct impact on thrombus formation. Optimised stent implantation is required to minimise malapposition in DES and BVS to reduce thrombus formation.
Journal title abbreviation:: EuroIntervention
Year:: 2017
Journal volume:: 13
Journal issue:: 9
Pages contribution:: e1096-e1098
Language:: eng
Fulltext / DOI:: doi:10.4244/EIJ-D-17-00381
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/28781241
Print-ISSN:: 1774-024X
TUM Institution:: Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
BibTeX

Occurrences: