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Document type:
journal article 
Author(s):
Vennemann, Antje; Alessandrini, Francesca; Wiemann, Martin 
Title:
Differential Effects of Surface-Functionalized Zirconium Oxide Nanoparticles on Alveolar Macrophages, Rat Lung, and a Mouse Allergy Model. 
Abstract:
Nanoparticles (NPs) may affect the lung via their chemical composition on the surface. Here, we compared the bioactivity of zirconium oxide (ZrO?) NPs coated with either aminopropilsilane (APTS), tetraoxidecanoic acid (TODS), polyethyleneglycol (PGA), or acrylic acid (Acryl). Supernatants from NPs-treated cultured alveolar macrophages (NR8383) tested for lactate dehydrogenase, glucuronidase, tumor necrosis factor ?, and H?O? formation revealed dose-dependent effects, with only gradual difference...    »
 
Journal title abbreviation:
Nanomaterials (Basel) 
Year:
2017 
Journal volume:
Journal issue:
Language:
eng 
Print-ISSN:
2079-4991 
TUM Institution:
Institut für Molekulare Allergologie