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Document type:
journal article 
Author(s):
Dietz, Katharina; de Los Reyes Jiménez, Marta; Gollwitzer, Eva S; Chaker, Adam M; Zissler, Ulrich M; Rådmark, Olof P; Baarsma, Hoeke A; Königshoff, Melanie; Schmidt-Weber, Carsten B; Marsland, Benjamin J; Esser-von Bieren, Julia 
Title:
Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways. 
Abstract:
Airway remodeling is a detrimental and refractory process showing age-dependent clinical manifestations that are mechanistically undefined. The leukotriene (LT) and wingless/integrase (Wnt) pathways have been implicated in remodeling, but age-specific expression profiles and common regulators remained elusive.We sought to study the activation of the LT and Wnt pathways during early- or late-onset allergic airway inflammation and to address regulatory mechanisms and clinical relevance in normal h...    »
 
Journal title abbreviation:
J Allergy Clin Immunol 
Year:
2017 
Journal volume:
139 
Journal issue:
Pages contribution:
1343-1354.e6 
Language:
eng 
Print-ISSN:
0091-6749 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung; Hals-, Nasen-, Ohrenklinik und Poliklinik