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Document type:
journal article 
Author(s):
Muschaweckh, Andreas; Petermann, Franziska; Korn, Thomas 
Title:
IL-1? and IL-23 Promote Extrathymic Commitment of CD27+CD122- ?? T Cells to ??T17 Cells. 
Abstract:
??T17 cells are a subset of ?? T cells committed to IL-17 production and are characterized by the expression of IL-23R and CCR6 and lack of CD27 expression. ??T17 cells are believed to arise within a narrow time window during prenatal thymic development. In agreement with this concept, we show in this study that adult Rag1-/- recipient mice of Il23rgfp/+ (IL-23R reporter) bone marrow selectively lack IL-23R+ ??T17 cells. Despite their absence in secondary lymphoid tissues during homeostasis, ??T...    »
 
Journal title abbreviation:
J Immunol 
Year:
2017 
Journal volume:
199 
Journal issue:
Pages contribution:
2668-2679 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Klinik und Poliklinik für Neurologie; Lehrstuhl für Molekulare Neuroimmunologie (Prof. Korn)