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Document type:
journal article 
Author(s):
Tr?an, Tihana; Vukovi?, Kristina; Filipovi?, Petra; Brizi?, Ana Lesac; Lemmermann, Niels A W; Schober, Kilian; Busch, Dirk H; Britt, William J; Messerle, Martin; Krmpoti?, Astrid; Jonji?, Stipan 
Title:
Cytomegalovirus vector expressing RAE-1? induces enhanced anti-tumor capacity of murine CD8 T cells. 
Abstract:
Designing CD8 T-cell vaccines, which would provide protection against tumors is still considered a great challenge in immunotherapy. Here we show the robust potential of cytomegalovirus (CMV) vector expressing the NKG2D ligand RAE-1? as CD8 T cell-based vaccine against malignant tumors. Immunization with the CMV vector expressing RAE-1?, delayed tumor growth or even provided complete protection against tumor challenge in both prophylactic and therapeutic settings. Moreover, a potent tumor contro...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2017 
Journal volume:
47 
Journal issue:
Pages contribution:
1354-1367 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene