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Document type:
journal article 
Author(s):
Thiel, Uwe; Schober, Sebastian J; Einspieler, Ingo; Kirschner, Andreas; Thiede, Melanie; Schirmer, David; Gall, Katja; Blaeschke, Franziska; Schmidt, Oxana; Jabar, Susanne; Ranft, Andreas; Alba Rubío, Rebeca; Dirksen, Uta; Grunewald, Thomas G P; Sorensen, Poul H; Richter, Günther H S; von Lüttichau, Irene Teichert; Busch, Dirk H; Burdach, Stefan E G 
Title:
Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A*02:01-specific allorestricted T cell receptor transgenic T cells. 
Abstract:
: Chondromodulin-I (CHM1) sustains malignancy in Ewing sarcoma (ES). Refractory ES carries a dismal prognosis and patients with bone marrow (BM) metastases do not survive irrespective of therapy. We assessed HLA-A*02:01/CHM1-specific allorestricted T cell receptor (TCR) wild-type and transgenic cytotoxic (CD8) T cells against ES. : Three refractory HLA-A2 ES patients were treated with HLA-A*02:01/peptide-specific allorepertoire-derived (i.e., allorestricted) CD8 T cells. Patient #1 received up t...    »
 
Journal title abbreviation:
Oncoimmunology 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
e1312239 
Language:
eng 
Print-ISSN:
2162-4011 
TUM Institution:
Klinik und Poliklinik für Kinder- und Jugendmedizin; Klinik und Poliklinik für Nuklearmedizin; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene