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Document type:
journal article 
Author(s):
Groba, Sara Reinartz; Guttmann, Sarah; Niemietz, Christoph; Bernick, Friedrich; Sauer, Vanessa; Hachmöller, Oliver; Karst, Uwe; Zischka, Hans; Zibert, Andree; Schmidt, Hartmut H 
Title:
Downregulation of hepatic multi-drug resistance protein 1 (MDR1) after copper exposure. 
Abstract:
Copper homeostasis is strictly regulated in mammalian cells. We investigated the adaptation of hepatocytes after long-term copper exposure. Copper-resistant hepatoma HepG2 cell lines lacking ATP7B were generated. Growth, copper accumulation, gene expression, and transport were determined. Hepatocyte-like cells derived from a Wilson disease (WD) patient and the liver of a WD animal model were also studied. The rapidly gained copper resistance was found to be stable, as subculturing of cells in th...    »
 
Journal title abbreviation:
Metallomics 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
1279-1287 
Language:
eng 
Print-ISSN:
1756-5901 
TUM Institution:
Institut für Toxikologie und Umwelthygiene