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Document type:
journal article 
Author(s):
Hachmöller, Oliver; Zibert, Andree; Zischka, Hans; Sperling, Michael; Groba, Sara Reinartz; Grünewald, Inga; Wardelmann, Eva; Schmidt, Hartmut H-J; Karst, Uwe 
Title:
Spatial investigation of the elemental distribution in Wilson's disease liver after d-penicillamine treatment by LA-ICP-MS. 
Abstract:
At present, the copper chelator d-penicillamine (DPA) is the first-line therapy of Wilson's disease (WD), which is characterized by an excessive copper overload. Lifelong DPA treatments aim to reduce the amount of detrimental excess copper retention in the liver and other organs. Although DPA shows beneficial effect in many patients, it may cause severe adverse effects. Despite several years of copper chelation therapy, discontinuation of DPA therapy can be linked to a rapidly progressing liver...    »
 
Journal title abbreviation:
J Trace Elem Med Biol 
Year:
2017 
Journal volume:
44 
Pages contribution:
26-31 
Language:
eng 
Print-ISSN:
0946-672X 
TUM Institution:
Institut für Toxikologie und Umwelthygiene