Purpose. Quantitative and automatic analysis of intracoronary optical coherence tomography images is useful to assess cardiovascular risk in the clinical arena. Methods. First, the interfaces of the intima, media and adventitia layers are segmented, by means of an original front propagation scheme, running in a multi-parametric space, to simultaneously extract three non-crossing contours in the initial cross-sectional image. Second, information resulting from the tentative contours is exploited by a machine learning approach to identify healthy an diseased regions of the arterial wall. The framework is fully automatic. Results. The method was applied to 40 patients from two different medical centers. The framework was trained on 140 images and validated on 260 other images. For the contour segmentation method, the average segmentation errors were 29±46 µm for the Intima-Media interface, 30±50 µm for the Media-Adventitia interface, and 50±64 µm for the Adventitia-Periadventitia interface. The classification method demonstrated a good accuracy, with a median Dice coefficient equal to 0.91 and an interquartile range of [0.77-0.97]. Conclusion. The proposed framework demonstrated promising offline performances and could potentially be translated into a reliable tool for various clinical applications, such as quantification of tissue layer thickness and global summarization of healthy regions in entire pullbacks.     «

Purpose. Quantitative and automatic analysis of intracoronary optical coherence tomography images is useful to assess cardiovascular risk in the clinical arena. Methods. First, the interfaces of the intima, media and adventitia layers are segmented, by means of an original front propagation scheme, running in a multi-parametric space, to simultaneously extract three non-crossing contours in the initial cross-sectional image. Second, information resulting from the tentative contours is exploit...     »