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Document type:
Journal Article; Article 
Author(s):
Weil, Marie-Theres; Möbius, Wiebke; Winkler, Anne; Ruhwedel, Torben; Wrzos, Claudia; Romanelli, Elisa; Bennett, Jeffrey L; Enz, Lukas; Goebels, Norbert; Nave, Klaus-Armin; Kerschensteiner, Martin; Schaeren-Wiemers, Nicole; Stadelmann, Christine; Simons, Mikael 
Title:
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases. 
Abstract:
Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin and found that myelin lamellae are broken down into vesicular structures at the innermost region of the myelin sheath. We demonstrated that myelin basic proteins (MBP), which form a polymer in between the myelin membrane layers, are targeted in t...    »
 
Journal title abbreviation:
Cell Rep 
Year:
2016 
Journal volume:
16 
Journal issue:
Pages contribution:
314-22 
Language:
eng 
Print-ISSN:
2211-1247 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)