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Document type:
Journal Article; Article 
Author(s):
Romanelli, Elisa; Merkler, Doron; Mezydlo, Aleksandra; Weil, Marie-Theres; Weber, Martin S; Niki?, Ivana; Potz, Stephanie; Meinl, Edgar; Matznick, Florian E H; Kreutzfeldt, Mario; Ghanem, Alexander; Conzelmann, Karl-Klaus; Metz, Imke; Brück, Wolfgang; Routh, Matthew; Simons, Mikael; Bishop, Derron; Misgeld, Thomas; Kerschensteiner, Martin 
Title:
Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. 
Abstract:
Oligodendrocyte damage is a central event in the pathogenesis of the common neuroinflammatory condition, multiple sclerosis (MS). Where and how oligodendrocyte damage is initiated in MS is not completely understood. Here, we use a combination of light and electron microscopy techniques to provide a dynamic and highly resolved view of oligodendrocyte damage in neuroinflammatory lesions. We show that both in MS and in its animal model structural damage is initiated at the myelin sheaths and only l...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2016 
Journal volume:
Pages contribution:
13275 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
2041-1723 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)