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Document type:
journal article 
Author(s):
Mayorga, Orlando; Bühler, Silja; Jaeger, Veronika K; Bally, Seraina; Hatz, Christoph; Frösner, Gert; Protzer, Ulrike; Van Damme, Pierre; Egger, Matthias; Herzog, Christian 
Title:
Single-Dose Hepatitis A Immunization: 7.5-Year Observational Pilot Study in Nicaraguan Children to Assess Protective Effectiveness and Humoral Immune Memory Response. 
Abstract:
Universal 2-dose hepatitis A virus (HAV) vaccination of toddlers effectively controls hepatitis A. High vaccine costs, however, impede implementation in endemic countries. To test single-dose vaccination as a possible alternative, we initiated an observational, longitudinal study in Nicaragua, to assess protective effectiveness and-through challenge vaccination-humoral immune memory response. After a 2003 serosurvey, 130 originally seronegative children received one dose of virosomal HAV vaccine...    »
 
Journal title abbreviation:
J Infect Dis 
Year:
2016 
Journal volume:
214 
Journal issue:
10 
Pages contribution:
1498-1506 
Language:
eng 
Print-ISSN:
0022-1899 
TUM Institution:
Institut für Virologie