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Document type:
journal article 
Author(s):
Michler, Thomas; Große, Stefanie; Mockenhaupt, Stefan; Röder, Natalie; Stückler, Ferdinand; Knapp, Bettina; Ko, Chunkyu; Heikenwalder, Mathias; Protzer, Ulrike; Grimm, Dirk 
Title:
Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA. 
Abstract:
Hepatitis B virus (HBV) is a promising target for therapies based on RNA interference (RNAi) since it replicates via RNA transcripts that are vulnerable to RNAi silencing. Clinical translation of RNAi technology, however, requires improvements in potency, specificity and safety. To this end, we systematically compared different strategies to express anti-HBV short hairpin RNA (shRNA) in a pre-clinical immunocompetent hepatitis B mouse model. Using recombinant Adeno-associated virus (AAV) 8 vecto...    »
 
Journal title abbreviation:
EMBO Mol Med 
Year:
2016 
Journal volume:
Journal issue:
Pages contribution:
1082-98 
Language:
eng 
Print-ISSN:
1757-4676 
TUM Institution:
Institut für Virologie