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Document type:
journal article 
Author(s):
Broecker, Felix; Hardt, Christopher; Herwig, Ralf; Timmermann, Bernd; Kerick, Martin; Wunderlich, Andrea; Schweiger, Michal R; Borsig, Lubor; Heikenwalder, Mathias; Lehrach, Hans; Moelling, Karin 
Title:
Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line. 
Abstract:
Deletions at the C-terminus of the proto-oncogene protein c-Src kinase are found in the viral oncogene protein v-Src as well as in some advanced human colon cancers. They are associated with increased kinase activity and cellular invasiveness. Here, we analyzed the mRNA expression signature of a constitutively active C-terminal mutant of c-Src, c-Src(mt), in comparison with its wild-type protein, c-Src(wt), in the human non-transformed breast epithelial cell line MCF-10A. We demonstrated previou...    »
 
Journal title abbreviation:
FEBS J 
Year:
2016 
Journal volume:
283 
Journal issue:
Pages contribution:
1669-88 
Language:
eng 
Print-ISSN:
1742-464X 
TUM Institution:
Institut für Virologie