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Document type:
journal article 
Author(s):
Ma, Chi; Kesarwala, Aparna H; Eggert, Tobias; Medina-Echeverz, José; Kleiner, David E; Jin, Ping; Stroncek, David F; Terabe, Masaki; Kapoor, Veena; ElGindi, Mei; Han, Miaojun; Thornton, Angela M; Zhang, Haibo; Egger, Michèle; Luo, Ji; Felsher, Dean W; McVicar, Daniel W; Weber, Achim; Heikenwalder, Mathias; Greten, Tim F 
Title:
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. 
Abstract:
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death. Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the US population and is considered to be a metabolic predisposition to liver cancer. However, the role of adaptive immune responses in NAFLD-promoted HCC is largely unknown. Here we show, in mouse models and human samples, that dysregulation of lipid metabolism in NAFLD causes a selective loss of intrahepatic CD4(+) but not CD8(+) T lymp...    »
 
Journal title abbreviation:
Nature 
Year:
2016 
Journal volume:
531 
Journal issue:
7593 
Pages contribution:
253-7 
Language:
eng 
Print-ISSN:
0028-0836 
TUM Institution:
Institut für Virologie