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Document type:
journal article 
Author(s):
Spinner, S; Crispatzu, G; Yi, J-H; Munkhbaatar, E; Mayer, P; Höckendorf, U; Müller, N; Li, Z; Schader, T; Bendz, H; Hartmann, S; Yabal, M; Pechloff, K; Heikenwalder, M; Kelly, G L; Strasser, A; Peschel, C; Hansmann, M-L; Ruland, J; Keller, U; Newrzela, S; Herling, M; Jost, P J 
Title:
Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance. 
Abstract:
T lymphocyte non-Hodgkin's lymphoma (T-NHL) represents an aggressive and largely therapy-resistant subtype of lymphoid malignancies. As deregulated apoptosis is a frequent hallmark of lymphomagenesis, we analyzed gene expression profiles and protein levels of primary human T-NHL samples for various apoptotic regulators. We identified the apoptotic regulator MCL-1 as the only pro-survival BCL-2 family member to be highly expressed throughout all human T-NHL subtypes. Functional validation of pro-...    »
 
Journal title abbreviation:
Leukemia 
Year:
2016 
Journal volume:
30 
Journal issue:
Pages contribution:
1520-30 
Language:
eng 
Print-ISSN:
0887-6924 
TUM Institution:
III. Medizinische Klinik und Poliklinik; Institut für Klinische Chemie und Pathobiochemie; Institut für Virologie