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Document type:
journal article 
Author(s):
Price, Dominique N; McBride, Amber A; Anton, Martina; Kusewitt, Donna F; Norenberg, Jeffrey P; MacKenzie, Debra A; Thompson, Todd A; Muttil, Pavan 
Title:
Longitudinal Assessment of Lung Cancer Progression in Mice Using the Sodium Iodide Symporter Reporter Gene and SPECT/CT Imaging. 
Abstract:
Lung cancer has the highest mortality rate of any tissue-specific cancer in both men and women. Research continues to investigate novel drugs and therapies to mitigate poor treatment efficacy, but the lack of a good descriptive lung cancer animal model for preclinical drug evaluation remains an obstacle. Here we describe the development of an orthotopic lung cancer animal model which utilizes the human sodium iodide symporter gene (hNIS; SLC5A5) as an imaging reporter gene for the purpose of no...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2016 
Journal volume:
11 
Journal issue:
12 
Pages contribution:
e0169107 
Language:
eng 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung