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Document type:
journal article 
Author(s):
Vosen, Sarah; Rieck, Sarah; Heidsieck, Alexandra; Mykhaylyk, Olga; Zimmermann, Katrin; Plank, Christian; Gleich, Bernhard; Pfeifer, Alexander; Fleischmann, Bernd K; Wenzel, Daniela 
Title:
Improvement of vascular function by magnetic nanoparticle-assisted circumferential gene transfer into the native endothelium. 
Abstract:
Gene therapy is a promising approach for chronic disorders that require continuous treatment such as cardiovascular disease. Overexpression of vasoprotective genes has generated encouraging results in animal models, but not in clinical trials. One major problem in humans is the delivery of sufficient amounts of genetic vectors to the endothelium which is impeded by blood flow, whereas prolonged stop-flow conditions impose the risk of ischemia. In the current study we have therefore developed a s...    »
 
Journal title abbreviation:
J Control Release 
Year:
2016 
Journal volume:
241 
Pages contribution:
164-173 
Language:
eng 
Print-ISSN:
0168-3659 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung