User: Guest  Login
Document type:
journal article 
Author(s):
Grünwald, Barbara; Vandooren, Jennifer; Gerg, Michael; Ahomaa, Kaarin; Hunger, Annique; Berchtold, Sonja; Akbareian, Sophia; Schaten, Susanne; Knolle, Percy; Edwards, Dylan R; Opdenakker, Ghislain; Krüger, Achim 
Title:
Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow. 
Abstract:
Matrix metalloproteinase 9 (MMP-9/Gelatinase B) is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and plays a central role in tumor cell invasion and metastasis. Here we complemented mechanistic insights in the cancer biology of MMP-9 and investigated the effects of specific long-term loss-of-function, by genetic ablation, of MMP-9 on PDAC initiation and progression in the well-established KPC mouse model of spontaneous PDAC. Tumor growth and progression were analyzed by histopathology...    »
 
Journal title abbreviation:
Mol Cancer Res 
Year:
2016 
Journal volume:
14 
Journal issue:
11 
Pages contribution:
1147-1158 
Language:
eng 
Print-ISSN:
1541-7786 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung