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Document type:
journal article 
Author(s):
Grünwald, Barbara; Vandooren, Jennifer; Locatelli, Erica; Fiten, Pierre; Opdenakker, Ghislain; Proost, Paul; Krüger, Achim; Lellouche, Jean Paul; Israel, Liron Limor; Shenkman, Louis; Comes Franchini, Mauro 
Title:
Matrix metalloproteinase-9 (MMP-9) as an activator of nanosystems for targeted drug delivery in pancreatic cancer. 
Abstract:
Specific cancer cell targeting is a pre-requisite for efficient drug delivery as well as for high-resolution imaging and still represents a major technical challenge. Tumor-associated enzyme-assisted targeting is a new concept that takes advantage of the presence of a specific activity in the tumor entity. MMP-9 is a protease found to be upregulated in virtually all malignant tumors. Consequently, we hypothesized that its presence can provide a de-shielding activity for targeted delivery of drug...    »
 
Journal title abbreviation:
J Control Release 
Year:
2016 
Journal volume:
239 
Pages contribution:
39-48 
Language:
eng 
Print-ISSN:
0168-3659 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung