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Document type:
journal article 
Author(s):
Jarz?bi?ska, Anita; Pasewald, Tamara; Lambrecht, Jana; Mykhaylyk, Olga; Kümmerling, Linda; Beck, Philipp; Hasenpusch, Günther; Rudolph, Carsten; Plank, Christian; Dohmen, Christian 
Title:
A Single Methylene Group in Oligoalkylamine-Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery. 
Abstract:
The development of chemically modified mRNA holds great promise as a new class of biologic therapeutics. However, the intracellular delivery and endosomal escape of mRNA encapsulated in nanoparticles has not been systematically investigated. Here, we synthesized a diverse set of cationic polymers and lipids from a series of oligoalkylamines and subsequently characterized their mRNA delivery capability. Notably, a structure with an alternating alkyl chain length between amines showed the highest...    »
 
Journal title abbreviation:
Angew Chem Int Ed Engl 
Year:
2016 
Journal volume:
55 
Journal issue:
33 
Pages contribution:
9591-5 
Language:
eng 
Print-ISSN:
0570-0833 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung