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Document type:
journal article 
Author(s):
Heine, Annkristin; Schilling, Judith; Grünwald, Barbara; Krüger, Achim; Gevensleben, Heidrun; Held, Stefanie Andrea Erika; Garbi, Natalio; Kurts, Christian; Brossart, Peter; Knolle, Percy; Diehl, Linda; Höchst, Bastian 
Title:
The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib. 
Abstract:
Increased numbers of immunosuppressive myeloid derived suppressor cells (MDSCs) correlate with a poor prognosis in cancer patients. Tyrosine kinase inhibitors (TKIs) are used as standard therapy for the treatment of several neoplastic diseases. However, TKIs not only exert effects on the malignant cell clone itself but also affect immune cells. Here, we investigate the effect of TKIs on the induction of MDSCs that differentiate from mature human monocytes using a new in vitro model of MDSC induc...    »
 
Journal title abbreviation:
Cancer Immunol Immunother 
Year:
2016 
Journal volume:
65 
Journal issue:
Pages contribution:
273-82 
Language:
eng 
Print-ISSN:
0340-7004 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung; Institut für Molekulare Immunologie