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Document type:
journal article 
Author(s):
Kolk, Andreas; Tischer, Thomas; Koch, Christian; Vogt, Stephan; Haller, Bernhard; Smeets, Ralf; Keutzer, Kilian; Plank, Christian; Bissinger, Oliver 
Title:
A novel nonviral gene delivery tool of BMP-2 for the reconstitution of critical-size bone defects in rats. 
Abstract:
The osseointegration of bone implants, implant failure, and the bridging of critical-size bone defects are frequent clinical challenges. Deficiencies in endogenous bone healing can be resolved through the local administration of suitable recombinant growth factors (GFs). In preclinical models, gene-therapy-supported bone healing has proven promising for overcoming certain limitations of GFs. We report the dose-dependent bridging of critical-size mandibular bone defects (CSDs) in a rat model usin...    »
 
Journal title abbreviation:
J Biomed Mater Res A 
Year:
2016 
Journal volume:
104 
Journal issue:
10 
Pages contribution:
2441-55 
Language:
eng 
Print-ISSN:
1549-3296 
TUM Institution:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie; Institut für experimentelle Onkologie und Therapieforschung; Institut für Medizinische Statistik und Epidemiologie