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Dokumenttyp:
journal article 
Autor(en):
Hassan, Zonera; Schneeweis, Christian; Wirth, Matthias; Veltkamp, Christian; Dantes, Zahra; Feuerecker, Benedikt; Ceyhan, Güralp O; Knauer, Shirley K; Weichert, Wilko; Schmid, Roland M; Stauber, Roland; Arlt, Alexander; Krämer, Oliver H; Rad, Roland; Reichert, Maximilian; Saur, Dieter; Schneider, Günter 
Titel:
MTOR inhibitor-based combination therapies for pancreatic cancer. 
Abstract:
Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification.We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and...    »
 
Zeitschriftentitel:
Br J Cancer 
Jahr:
2018 
Band / Volume:
118 
Heft / Issue:
Seitenangaben Beitrag:
366-377 
Sprache:
eng 
Print-ISSN:
0007-0920 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie