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Dokumenttyp:
journal article 
Autor(en):
Vogel, Anna-Lena; Knier, Benjamin; Lammens, Katja; Kalluri, Sudhakar Reddy; Kuhlmann, Tanja; Bennett, Jeffrey L; Korn, Thomas 
Titel:
Deletional tolerance prevents AQP4-directed autoimmunity in mice. 
Abstract:
Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system (CNS) mediated by antibodies to the water channel protein AQP4 expressed in astrocytes. The contribution of AQP4-specific T cells to the class switch recombination of pathogenic AQP4-specific antibodies and the inflammation of the blood-brain barrier is incompletely understood, as immunogenic naturally processed T-cell epitopes of AQP4 are unknown. By immunizing Aqp4-/- mice with full-length murine AQP4 protein fo...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2017 
Band / Volume:
47 
Heft / Issue:
Seitenangaben Beitrag:
458-469 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
Klinik und Poliklinik für Neurologie; Lehrstuhl für Molekulare Neuroimmunologie (Prof. Korn)