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Document type:
journal article 
Author(s):
Kong, Bo; Bruns, Philipp; Behler, Nora A; Chang, Ligong; Schlitter, Anna Melissa; Cao, Jing; Gewies, Andreas; Ruland, Jürgen; Fritzsche, Sina; Valkovskaya, Nataliya; Jian, Ziying; Regel, Ivonne; Raulefs, Susanne; Irmler, Martin; Beckers, Johannes; Friess, Helmut; Erkan, Mert; Mueller, Nikola S; Roth, Susanne; Hackert, Thilo; Esposito, Irene; Theis, Fabian J; Kleeff, Jörg; Michalski, Christoph W 
Title:
Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy. 
Abstract:
The initial steps of pancreatic regeneration versus carcinogenesis are insufficiently understood. Although a combination of oncogenic Kras and inflammation has been shown to induce malignancy, molecular networks of early carcinogenesis remain poorly defined.We compared early events during inflammation, regeneration and carcinogenesis on histological and transcriptional levels with a high temporal resolution using a well-established mouse model of pancreatitis and of inflammation-accelerated Kras...    »
 
Journal title abbreviation:
Gut 
Year:
2018 
Journal volume:
67 
Journal issue:
Pages contribution:
146-156 
Language:
eng 
Print-ISSN:
0017-5749 
TUM Institution:
Chirurgiesche Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie; Institut für Klinische Chemie und Pathobiochemie