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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Fromme, Tobias; Kleigrewe, Karin; Dunkel, Andreas; Retzler, Angelika; Li, Yongguo; Maurer, Stefanie; Fischer, Natascha; Diezko, Rolf; Kanzleiter, Timo; Hirschberg, Verena; Hofmann, Thomas; Klingenspor, Martin 
Titel:
Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity 
Abstract:
Objective Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition. We measured the cellular concentration and the release of purine nucleotide metabolites to uncover a possible role of purine nucleotide degradation in uncoupling protein 1 activation. Methods...    »
 
Stichworte:
Purine nucleotides, Uncoupling protein 1, Brown adipose tissue, Non-shivering thermogenesis, HILIC-MS/MS, Guanosine monophosphate reductase 
Zeitschriftentitel:
Molecular Metabolism 
Jahr:
2017 
Verlag / Institution:
Elsevier BV 
E-ISSN:
2212-8778 
Publikationsdatum:
01.12.2017