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Document type:
Zeitschriftenaufsatz 
Author(s):
Fromme, Tobias; Kleigrewe, Karin; Dunkel, Andreas; Retzler, Angelika; Li, Yongguo; Maurer, Stefanie; Fischer, Natascha; Diezko, Rolf; Kanzleiter, Timo; Hirschberg, Verena; Hofmann, Thomas; Klingenspor, Martin 
Title:
Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity 
Abstract:
Objective Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition. We measured the cellular concentration and the release of purine nucleotide metabolites to uncover a possible role of purine nucleotide degradation in uncoupling protein 1 activation. Methods Wit...    »
 
Keywords:
Purine nucleotides, Uncoupling protein 1, Brown adipose tissue, Non-shivering thermogenesis, HILIC-MS/MS, Guanosine monophosphate reductase 
Journal title:
Molecular Metabolism 
Year:
2017 
Publisher:
Elsevier BV 
E-ISSN:
2212-8778 
Date of publication:
01.12.2017