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Document type:
journal article 
Author(s):
Kaittanis, Charalambos; Andreou, Chrysafis; Hieronymus, Haley; Mao, Ninghui; Foss, Catherine A; Eiber, Matthias; Weirich, Gregor; Panchal, Palak; Gopalan, Anuradha; Zurita, Juan; Achilefu, Samuel; Chiosis, Gabriela; Ponomarev, Vladimir; Schwaiger, Markus; Carver, Brett S; Pomper, Martin G; Grimm, Jan 
Title:
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors. 
Abstract:
Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in prostate cancer remained elusive. Filling this gap, we demonstrate that in prostate cancer, PSMA initiates signaling upstream of PI3K through G protein-coupled receptors, specifically via the metabotropic glutamate receptor (mGluR...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2018 
Journal volume:
215 
Journal issue:
Pages contribution:
159-175 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1007 
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin; Institut für Allgemeine Pathologie und pathologische Anatomie