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Dokumenttyp:
journal article 
Autor(en):
Kaittanis, Charalambos; Andreou, Chrysafis; Hieronymus, Haley; Mao, Ninghui; Foss, Catherine A; Eiber, Matthias; Weirich, Gregor; Panchal, Palak; Gopalan, Anuradha; Zurita, Juan; Achilefu, Samuel; Chiosis, Gabriela; Ponomarev, Vladimir; Schwaiger, Markus; Carver, Brett S; Pomper, Martin G; Grimm, Jan 
Titel:
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors. 
Abstract:
Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in prostate cancer remained elusive. Filling this gap, we demonstrate that in prostate cancer, PSMA initiates signaling upstream of PI3K through G protein-coupled receptors, specifically via the metabotropic glutamate receptor (mGluR...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2018 
Band / Volume:
215 
Heft / Issue:
Seitenangaben Beitrag:
159-175 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin; Institut für Allgemeine Pathologie und pathologische Anatomie