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Document type:
journal article 
Author(s):
Frejno, Martin; Zenezini Chiozzi, Riccardo; Wilhelm, Mathias; Koch, Heiner; Zheng, Runsheng; Klaeger, Susan; Ruprecht, Benjamin; Meng, Chen; Kramer, Karl; Jarzab, Anna; Heinzlmeir, Stephanie; Johnstone, Elaine; Domingo, Enric; Kerr, David; Jesinghaus, Moritz; Slotta-Huspenina, Julia; Weichert, Wilko; Knapp, Stefan; Feller, Stephan M; Kuster, Bernhard 
Title:
Pharmacoproteomic characterisation of human colon and rectal cancer. 
Abstract:
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome-guided pre-clinical drug sensitivity studies are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of> 10,000 proteins using mass spectrometry. Integration with proteomes of 90 CRC patients and matched transcriptomics data defined integrated CRC subtypes, highlighting cell lines representative of each tumou...    »
 
Journal title abbreviation:
Mol Syst Biol 
Year:
2017 
Journal volume:
13 
Journal issue:
11 
Pages contribution:
951 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie